• Chemotherapy is sometimes considered when surgery or radiotherapy are refused or have already been used as
  much as they can be. Prospects for cure in this situation are low and prolonging life is the goal of therapy.
• For patients whose disease has spread beyond the neck, no curative treatment is available.
• There are several investigational protocols in use, including chemotherapy, radiation therapy with neutron
  beams, or radiation accompanied by anticancer drugs such as doxorubicin , cisplatin , carboplatin ,
  cyclophosphamide and 5-fluorouracil.

Treatment by Stage 
Stage I 
Standard Treatment 
• For low-grade tumors, surgery alone. Radiotherapy may be an alternative if surgery would cause significant
  cosmetic or functional problems. Radiotherapy is also used after surgery if the margins are involved. Fast
  neutron beam radiotherapy may be used for tumors that have spread to lymph nodes .
• For high-grade tumors, surgery alone, although adjuvant radiotherapy may also be given (especially with
  positive surgical margins). If the tumor cannot be removed, radiotherapy may be used for palliation. If the
  tumor has spread to the neck lymph nodes, these nodes should be removed.
      Local recurrence may be reduced by adjuvant radiotherapy. Neutron beam radiation is under clinical
  evaluation, and recent studies indicate that these tumors may also respond to chemotherapy.